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One antibody, ZK2B10, showed the most potent neutralization activity, completely protected uninfected mice, and markedly reduced tissue pathology in infected mice.
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Jiang, L. et al. Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein.
Sub-neutralizing concentrations of antibodies 2G4 or m8C4 enabled non-neutralizing antibody FVM09 (IC50 >1 μM) to exhibit potent neutralization (IC50 1–10 nM).
As the immunoglobulin (Ig) content of ascitic fluids may vary from 1 to 10 mg/ml, we repeated the same experiment with the most potent mAb of each group after purification to compare more precisely the neutralization activity of the different mAbs (Table 2).
Currently, inactivated whole-virion EV71 vaccines appear to be the most potent vaccine candidates; however, immunological results are difficult to compare because the standard production methods, standard virus neutralization assays and the methods used to quantify the critical viral antigens are not available.
When tested at therapeutic levels (10ug/ml), VRC01 only neutralized 80% of viruses in the panel, although it did exhibit potent neutralization activity against sensitive viruses (IC50 titres of 0.42 μg/ml).
Ying, T. et al. Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies.
Huang, J. et al. Broad and potent neutralization of HIV-1 by a gp41-specific human antibody.
Height is our most potent architectural currency.
Instead he became its most potent critic.
"Which one is the most potent?
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