For cocaine use disorders (CUD), specifically, the most potent intervention currently available for initiating abstinence is behavior therapy using contingency management (CM) procedures, with early cessation being a robust predictor of future abstinence.
However, a Cochrane collaborative review of strategies to improve diabetes care reported that interventions that combine patient components with other components (physician or organization of care) are the most potent intervention strategies (12).
Isoniazid is still the most potent treatment targeting InhA enzyme.
Topical corticosteroids are currently the most potent treatment for AD.
To date, the most potent immune intervention after allo-SCT is a DLI.
To ensure independence of effect sizes for studies with multiple arms, we selected the contrast between the most theoretically potent intervention arm and the comparison arm that was typically a standard of care or wait list control.
Calorie restriction (CR) without malnutrition is the most potent and reproducible intervention for slowing aging and protecting against cancer in mammals [ 1, 2].
In animal models, they also produce some of the most potent cytoprotective (see Box 1) interventions in the field of ischemia-reperfusion biology, attenuating tissue injury by up to 80% (Murry et al., 1986).
When considering the effectiveness, tolerability, and cost of the various diabetes treatments, insulin is not only the most potent, but also the most cost-effective intervention (8).
