OCP crystals, the most potent inflammation-inducing BCP crystals [ 33, 34], are found in joint fluids [ 35].
Thus, division I-1 strains are the most potent inducers of inflammation and stimulation of sebocytes and keratinocytes, the latter by selective induction of human β-defensin-2 and interleukin-8 through Toll-like receptors 2 and 4 [6], [6].
One of the most potent drivers of inflammation is the cytokine IL-1β, which is produced in the cytoplasm in response to danger signals like LPS.
It has been well established that atherosclerosis is a chronic inflammatory disorder [ 5], with oxidized low-density lipoprotein (LDL) cholesterol being one of the most potent inducers of inflammation [ 6].
Sound evidence has been generated that oxidative stress is one of the most potent inductor of vascular inflammation in atherogenesis [6].
TNFα and IL1β are arguably the most potent cytokines involved in inducing inflammation.
The results demonstrated that compounds 10f and 11f exhibited the most potent neuroprotective effect against oxidative stress and inflammation, which is higher than that of the lead compound CAPE.
IL-1 receptor antagonist (IL-1ra) is an inactive member of the IL-1 family and represents one of the most potent mechanisms for controlling IL-1-dependent inflammation.
The screen revealed 35 chemicals capable of enhancing HSC engraftment, the most potent of which was dmPGE2, a known small lipid mediator of inflammation that is upregulated during marrow transplantation.
Prostaglandin (PG E2 is among the most potent and inducible of the prostanoids that are produced in states of inflammation.
Indeed, cilomilast was the most potent at early stage (days 4 and 7) of bleomycin-induced PF, when inflammation is the major characteristic of the pathological process [ 5].
