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The most potent inducer of GSH identified in this study, congener 6a, was minimally toxic to cells and was able to provide neuroprotection in the 6-OHDA model of neurotoxicity, suggesting GSH induction as a neuroprotective strategy.
Among the diversified carbon sources tested, starch was found to be the most potent inducer of amylase activity (2293.34 ± 30.3 U/g) from strain ALA4, while relatively lower amylase yield ranging from 612.12 ± 18.3 to 1834.23 ± 23.2 U/g was observed with other carbon sources used such as lactose, mannose, xylose, glucose, maltose, and sucrose (Fig. 2f).
The most potent inducer of VEGF gene expression is hypoxia [23].
IL-1β is the most potent inducer of KGF in fibroblasts.
Among these mediators, IL-1β appears to be the most potent inducer of KGF expression in fibroblasts derived from multiple tissues [65], [66].
Even though C18 2 was not the most potent inducer of gene expression, one could speculate that it likely represents the quantitatively most important dietary activator of PPARα, as the average intake of C18 2 is much higher than that of C18 3, C20 5 and C22 6.
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Other carbon substrates, such as xylose, arabinose and sophorose (one of the most potent inducers of T. reesei cellulases), do not induce β-glucosidase (BGL1) and, in high concentrations, even repress its formation [ 10, 34].
UFPs were shown to be the most potent inducers of oxidative stress in macrophages and epithelial cells by inducing heme oxygenase-1 and depleting intracellular glutathione.
Furthermore, the elevated levels of IL-6 may also be contributing to increasing the systemic levels of the inflammatory marker CRP in the trained obese animals, since IL-6 is one of the most potent inducers of CRP release from the liver [ 7] and it can also induce the release of CRP from adipose tissue in MS [ 57].
Vascular Endothelial Growth Factor (VEGF) is one of the most potent inducers of angiogenesis and is up-regulated in carcinoma of the cervix.
Several 4,6-dimethoxy and 5-hydroxyaurones induced NQO1 activity of Hepa1c1c7 cells by 2-fold at submicromolar concentrations, making these the most potent inducers to be identified from this class.
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