Sentence examples for most potent hit from inspiring English sources

Compound 12 with IC50 of 2.8 μM is the most potent hit against BACE-1.

The most potent hit, 6a, displayed an EC50 value of 0.87 μM, which is very close to that of quinacrine (0.4 μM).

Compound 1 is the most potent hit against FABP4 with a selectivity of more than 144-fold preferences over human FABP3.

The most potent hit, 1c, was found to selectively and competitively inhibit the enzyme and inhibit the generation of ceramide in a dose-dependent manner.

The calculated binding mode of the most potent hit 36 guided us to design and synthesize a series of analogs (57a 57h).

Based on the docking modes of the most potent hit compound, a series of derivatives are synthesized, characterized and biological assayed on the PLK1, EEF2K as well as breast cancer cell proliferation models.

The most potent hits illustrated IC50 values of 4.2 and 2.60 μM against MDA-MB-231 cancer cell-line.

In order to identify small molecules with MEKK2 inhibitory activity, we screened a collection of known kinase inhibitors using a high throughput MEKK2 intrinsic ATPase enzyme assay and confirmed activity of the most potent hits with this primary assay.

The most potent hits were the statins, which stimulated growth of all mouse- and human-patient-derived neurons tested, both in vitro and in vivo, as did combined inhibition of the protein prenylation enzymes farnesyltransferase (PFT) and geranylgeranyl transferase I (PGGT-1).

"It was one of the most potent hits we identified from this chemical compound library," Liu said.

The most potent hits were evaluated for cytotoxicity, and those with clear subtoxic activity were investigated further.