These heterodimers are the most potent signaling complexes of the ERBB family [ 4] and are critical for the viability of breast cancer cells with ERBB2 gene amplification [ 11, 12].
"Lemonade" declares that misogyny is at its most potent and complex within the bonds of love.
The importance of ErbB3 is highlighted by the fact that ErbB3 is frequently overexpressed in breast cancer and ErbB2/ErbB3 heterodimer is the most potent oncogenic complex (36).
Ligand-induced heterodimerization between erbB3 and erbB2, the most potent signaling complex amongst the various heterodimers, is one likely mechanism of Herceptin resistance [ 55].
Although lacking intrinsic ligand-binding capability, HER2 acts as the preferred partner for the formation of mitogenically active heterodimers with the cognate EGFR family members epidermal growth factor 1 (HER1 or EGFR), EGFR receptor 3 (HER3), and receptor 4 (HER4) [ 4, 9, 10], HER2-HER3 being the prevalent and most potent of these complexes [ 1, 8, 11].
The cocrystallization of the most potent derivative in complex with the human immunodeficiency virus type 1 protease surprisingly led to two different crystal forms (P212121 and P6122).
The HER2/HER3 receptor pair form the most potent mitogenic receptor complex and HER2 overexpressing tumors frequently show phosphorylated HER3 [24].
The ErbB2/ErbB3 receptor pair forms the most potent mitogenic receptor complex in vitro (Pinkas-Kramarski et al, 1996b) and is key to the proliferation of human breast cancer cells (Holbro et al, 2003a).
These results show that for each antibody preparation, the soluble form of the peptide hapten is among the most potent inhibitors of complex formation with immobilized hapten, as expected.
Since Las17 is one of the most potent activators of Arp2/3 complex-mediated actin polymerization, it is discussed below (Mechanisms of Actin Assembly and Turnover).
