Sentence examples for most potent binding from inspiring English sources

Among the analogues, 13c exhibited the most potent binding affinity with a Ki = 0.7 μM.

JNK3 engages three arrestin-3 elements (Fig. 4), with the N-terminal 25 residues (T1A peptide) being the most potent binding site (Zhan et al., 2014).

Interestingly, the most potent binding inhibitors in adipocytes, namely fucoidan and PAz-PC, had no effect on mycobacterial attachment to 3T3-L1 pre-adipocytes (Figure 1B).

However, antipsychotics such as clozapine, olanzapine, risperidone, sertindole and zotepine have different propensities for inducing metabolic effects, even though they have similar and only moderate binding affinity for 5-HT2C receptors; moreover ziprasidone, which has the most potent binding [ 58], is apparently largely free of metabolic side effects.

Flow cytometric analysis indicated that compound 7c, one of the most potent p53 MDM2 binding inhibitors with a Ki value of 0.6 μM, showed its ability to arrest cell cycle progression.

Compound 18d displayed the most potent ERα binding affinity with RBA value of 2.83%, while 16d exhibited the best anti-proliferative activity against MCF-7 cells with IC50 value of 4.52 ± 2.47 μM.

Gelsolin is the most potent actin binding and severing protein identified to date which is widely expressed in mammalian tissues [ 22, 23].

Arg-Gly-Asp (RGD) sequence is one of the most potent integrin-binding ligand found in many native ECM proteins.

The most potent compound inhibits binding of CREBBP to chromatin in U2OS cells.

Figure 3 shows the dosing curves of the least potent compound 1 (saccharin) and the most potent compound 4 binding to all five tested CA isoforms.

TASP0376377 15-200), ofe of the most potent compounds, showed a potent binding affinity (IC50 = 19 nM) in addition to the excellent functional antagonist activity (IC50 = 13 nM).