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Adenosine, through activation of the A2A receptor (A2AR) subtype, ranks among the most potent agents limiting the inflammatory activities of neutrophils.
More than 20 cyanine dyes have been shown to exhibit neurotrophic effects, but NK-4 is one of the most potent agents for promotion of growth and differentiation of PC12 cells.
Zoledronic acid (ZA) is one of the most potent agents to block osteoclast function.
ROS are among the most potent agents and conditions that can alter methylation patterns in the liver, including DNA methylation.
Statins are the primary class of drugs used for managing LDL-C and are the most potent agents in lowering LDL-C.
GRFT is one of the most potent agents against human immunodeficiency virus (HIV), having 50% effective concentrations (EC50s) in the low-picomolar range (1).
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Among the more than 5,000 compounds that were screened, quercetin-3-rutinoside (rutin) emerged as the most potent agent.
(And the gentry are, often enough, the ambitious locals, as in Harlem, where Calvin Butts's Abyssinian Baptist Church is the single most potent agent of change).
Indeed, water, it is said at the outset, has an "extraordinary capacity…to catalyse essential chemical reactions", making it the Earth's "most potent agent of change".
Compound 16, a butyrophenone derivative of tetrahydroisoquinoline (THIQ), was identified as the most potent agent with low nanomolar binding affinities to both receptors.
Compound 5i was identified as one of the most potent agent with an IC50 120 times lower than those of the hits.
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