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All these compounds were found to be active, and N-ethyl isatin was found with the most potent activity of 69.7% protective effect on PC12 cells.
HAB-5A (30b) showed the most potent activity (IC50 = 0.53 μM) among the compounds prepared.
Among the compounds synthesized, 3d exhibited the most potent activity with low toxicity.
However only a phenyl substituted derivative was found to have most potent activity.
What's more, it showed the most potent activity against SaFabI with IC50 of 0.57 μM.
The S-isomer 12a of callophycin A showed the most potent activity in aromatase inhibition (IC50 = 10.5 μM).
9-Benzyl-2-butoxy-8-mercaptoadenine (9) indicated the most potent activity with MEC of 0.001 μM.
In particular, compound P3 displayed the most potent activity with IC50 value of 0.017 μM comparable with that of Imatinib.
Among the compounds tested, the compounds 7i and 8g displayed most potent activity with MIC value of 1.56 µg/mL with low cytotoxicity.
In particular, compounds 7aIII and 10a showed the most potent activity with the IC50 values of 18.44 nM and 13.58 nM, respectively.
In particular, compound 8u displayed the most potent activity against the replication of HBV DNA with IC50 value of 3.4 μM.
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