The most commonly postulated mechanism for the early copeptin elevation in acute illness is that copeptin reflects the activation of the hypothalamus-pituitary-adrenal axis at the hypothalamic level [41].
The most often postulated ones are PCLI, abnormal cytogenetics, β2M and CRP.
The most commonly postulated being the "insulin cancer hypothesis" [ 74], suggesting that obesity results in chronic hyperinsulinaemia.
Prostaglandin E2 (PGE2), nitric oxide (NO), indoleamine 2,3-dioxigenase (IDO), and programmed death ligand-1 (PD-L1) (also known as B7-H1) amongmong the most often postulated molecules to be involved in inhibition of T-cell proliferation by MSCs [ 10- 12].
The most frequently postulated risk factors for caesarean risk in migrant populations include: language/communication barriers, low SES, poor maternal health, gestational diabetes/high BMI, feto-pelvic disproportion, and lack of prenatal care.
Most religions postulate that the beginning was caused by a non-physical Creator (who I will call "God", but you can use the words "Universe", "Ground of Being", or "Pure Love", if it feels better) who deliberately created physicality for a purpose.
Although they have evolved independently for more than 500 million years, most models postulate a monophyletic origin for vertebrate and invertebrate immune systems that predates the bifurcation in their evolution.
Because TGF-β is a potent inducer of CTGF, most models postulate that CTGF acts as a downstream mediator of TGF-β activity, whereas other studies support an interdependent rather than merely sequential relationship between TGF-β and CTGF and their respective profibrotic activities [ 9- 11].
Most famously, Aristotle postulated the existence of a vegetal soul with its capacities for reproduction growth, and nourishment, as the most basic stratum of life.
