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Multiple grammar classifiers were generated to solve a 4‐way problem of assigning a helix pair to one of the four most populous classes.
In our study, we only considered the 4 most populous classes, because the other classes did not include sufficient number of members for automated training of classifiers.
In addition, when the helix pair classification problem was treated explicitely as a 4‐way problem of assigning a helix pair to one of the four most populous classes, our multiple grammar classifiers achieved an average A U C R O C of 0.65.
Note that percentages of helix‐helix contact sites from WDG and PDBTM datasets assigned to the four classes were similar for the most populous classes 1 and 2. Class 4 was overrepresented in the PDBTM at the expense of class 3 (see Additional file 2: Figure S2).
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In the most populous class 1 (29% of the helix pairs in the WDG set), the helices are arranged antiparallelly.
The peak f, at y = 0.470, is due to the predominance of examples with N = (1 0 0 1), which are from the 'Combined maintained new' class (the third most populous class).
Given that modulators of the G-protein coupled receptors comprise the most populous class of currently available drugs (Rosenbaum et al, 2009; Wang Lewisis, 2013), the validation of this concept and practical applications to eliminate IFNAR1 in acute life-threatening inflammatory syndromes is likely to be imminent.
Žirmūnai is the most populous administrative division (elderate) in Vilnius.
In our previous work (Taylor et al., 2013), these domain movements are in the 'Pure new' class (the most populous after the 'No-contact' class), meaning that in one conformation there are no contacts between the domains and in the other conformation there are exactly Nnew pairwise residue contacts.
As the world's most populous country, its burgeoning middle class offers massive opportunities.
São Paulo is the most populous Brazilian state (population ≈40 million).
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Justyna Jupowicz-Kozak
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