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The human TNF gene is located within the most polymorphic region of the human genome, the major histocompatibility complex (MHC) region of chromosome 6, which includes the human leukocyte antigen (HLA) genes [10].
The third step of the MLST scheme design consisted of selecting the most polymorphic region of ≈500 bp in length for each of the nine loci selected, and determining the sequence of this region in each strain of the entire validated collection, excluding one strain from each parent/derivative pair (Table S1).
The most polymorphic region of the PR gene was used as a model.
HLA alleles reside in the MHC region on chromosome 6, the most polymorphic region in the human genome [ 23].
As expected, the most polymorphic region was found in fragment 2, already known for including imperfect repeats [ 17].
These positions are located within the most polymorphic region; more specific rather than degenerated primers are needed at these sites.
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Macrosatellites are some of the most polymorphic regions of the human genome, yet many remain uncharacterized despite the association of some arrays with disease susceptibility.
Some of the most polymorphic regions of Stx2 are involved in receptor recognition [48] [50], suggesting that these changes confer a selective advantage, likely by altering host range specificity.
The major histocompatibility complex (MHC) is one of the most polymorphic regions in the vertebrate genome [ 1, 2].
The major histocompatibility complex (MHC) is one of the most polymorphic regions in human as well as in nonhuman primates and other mammal species studied.
AZFc is one of the most polymorphic regions in the human genome, with many AZFc architectures and DAZ gene structures being reported [ 11- 13].
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