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The major histocompatibility complex (MHC) is the most polymorphic locus known, with thousands of allelic variants.
Recent genome-wide association studies of HIV-1 clade B exposed cohorts have confirmed that HLA-B, which is the most polymorphic locus in the human genome, is the major genetic locus contributing to immune control of viraemia.
The most polymorphic locus was RM220 (8 alleles) and the least polymorphic locus was RM280 (3 alleles).
SSR locus 8 was the most polymorphic locus.
The most polymorphic locus (Bmac223) had 25 alleles; the least (Bmac579 and Bmac316) had four each.
Several studies recognized O157-10 as the most polymorphic locus [ 15, 19, 24, 30– 30].
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As most polymorphic loci had only two alleles, polymorphism prevalence (a binary metric either presence or absence of polymorphism) and not polymorphism level was estimated for each bin.
Most polymorphic loci exhibited macrogeographic uniformity of allele frequencies but in no case had any one allele become fixed in any one population.
Human leukocyte antigen (HLA) genes are the most polymorphic loci in the human genome and encode the highly polymorphic molecules critically involved in immune responses.
In addition, the HLA region is one of the most polymorphic loci in the human genome.
GMO 8 (41 alleles) and GMO 132 (30 alleles) represented the most polymorphic loci, whilst the Pan I locus (2 alleles) was the least polymorphic.
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