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It is the most polymorphic genomic region identified, and encodes proteins involved in the innate and adaptive immune responses [ 1, 2].
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Because the HLA region is the most polymorphic in the human genome, our results provide insights into the challenges of using of NGS data at other genomic regions of high diversity.
Another important finding is that most polymorphic mutations were present in different genomic contexts, suggesting that they were generated repeated times.
The HLA locus is among the most polymorphic in the human genome.
The HLA gene complex is different from other genomic regions by harbouring the most polymorphic genes we know; isotypic and allotypic polymorphism is in fact central to the physiological role of the class I and class II molecules.
Human leukocyte antigen (HLA) genes are the most polymorphic loci in the human genome and encode the highly polymorphic molecules critically involved in immune responses.
In addition, the HLA region is one of the most polymorphic loci in the human genome.
The X-linked G6PD gene is perhaps the most polymorphic gene in the human genome.
Thus far, the gp60 gene is the most polymorphic marker identified in the Cryptosporidium genome.
The MHC is known to be the most polymorphic gene region in vertebrates and, in humans, exhibits levels of nucleotide diversity that are two times higher than the genomic average [ 6].
The most polymorphic autosomal locus was D12S391, which presented 38 different sequence-based alleles.
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CEO of Professional Science Editing for Scientists @ prosciediting.com