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MHC genes are the most polymorphic genes described in vertebrates, with polymorphism occurring predominantly at residues involved in peptide binding (antigen binding sites, ABS; [ 5- 7]).
The HLA gene complex is different from other genomic regions by harbouring the most polymorphic genes we know; isotypic and allotypic polymorphism is in fact central to the physiological role of the class I and class II molecules.
The major histocompatibility complex (MHC) genes coding for antigen presenting molecules are the most polymorphic genes in vertebrate genome.
Based on Theta(pi), NAT2 ranks among the most polymorphic genes as compared to other drug metabolizing genes [28].
Some of the most polymorphic genes, such as those encoding components of the RecBCD pathway, made it possible to distinguish 24 haplotypes among the strains analyzed.
Recombination was detected by LDhat with statistical significance in the two most polymorphic genes, tonB (r/m ratio, 22.3; p = 0.02) and phoE (r/m ratio, 18.1; p = 0.0084), indicative of intragenic recombination in these genes.
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The most polymorphic gene region was fragment 2, and in samples where this region lacks polymorphism, all other regions are also identical.
GSTT1 was the most polymorphic gene in our set.
The pspA gene was clearly the most polymorphic gene fragment among the variable gene sequences; however, other less well-characterized surface proteins were also quite genetically diverse.
FXC1 was the most polymorphic gene in the initial analysis.
FXC1 was the most polymorphic gene with 18 detected alleles.
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