The DBL6ε domain has been described as the most polymorphic of the six DBL domains of var2csa, with an identity from 54 to 61% [23], [24].
Although most VAR2CSA DBL domains contain conserved and polymorphic domain regions that can be targeted by surface reactive antibodies [8], conserved regions are most prominent in DBL3X, DBL4X and DBL5ε.
In this study, we focused on exon 2 which encodes the peptide-binding region (B1 domain) and presents the most polymorphic part of the class IIB genes.
Sensitivity of rat macrophages to pyroptosis in response to LT is directly linked to the presence of certain short amino acid sequences at the most polymorphic site within the N-terminal NR100 domain.
The exon 2 domain of MHC is responsible for the recognition of diverse pathogens, and comprises the most polymorphic functional marker found in vertebrates [2].
The most polymorphic autosomal locus was D12S391, which presented 38 different sequence-based alleles.
Human leukocyte antigen (HLA) genes are the most polymorphic loci in the human genome and encode the highly polymorphic molecules critically involved in immune responses.
Vicia sativa is the most polymorphic species of the genus Vicia and the debate about its taxonomic classification is extensive.
The major histocompatibility complex (MHC) genes coding for antigen presenting molecules are the most polymorphic genes in vertebrate genome.
The most polymorphic locus was RM220 (8 alleles) and the least polymorphic locus was RM280 (3 alleles).
