Sentence examples for most point mutations from inspiring English sources

Like most point mutations, the majority are probably mildly deleterious.

While most point mutations showed no significant alteration in cellular localization, one, S285I (Figure 1), showed a significant defect in nuclear localization (p<0.0001; Table 1).

I know that most point mutations are phenotypically and selectively neutral or nearly neutral (fortunately).

In general, most point mutations probably give rise to no functional frataxin, and in many patients are associated with a more severe phenotype.

It is well known that the difference in mutation rates between autosomes and the X chromosome is due to the difference in the duration time in males, where most point mutations are generated in mammals.

Given the multicopy nature of mtDNA within cells, most point mutations are highly recessive and it is only when a point mutation clonally expands and reaches a critical threshold level that a respiratory chain defect is observed.

Most 21OHD patients are carriers of deletions of the gene encoding 21OH, CYP21A2, or of any of the 9 most frequent point mutations derived from the non-functional CYP21A1P pseudogene.

12 of the most frequent point mutations in exon 5, 7, and 8 of human p53 gene are included.

The target sequences harbor 12 of the most frequent point mutations in exon 5, 7, and 8 of human p53 gene (Table 1).

Conversely, most single point mutations throughout key conserved features in peripheral tertiary architecture supporting the SAM binding pocket have relatively little impact on riboswitch activity.

In the present work we developed a simple colorimetric assay using unmodified GNPs to detect 12 of the most frequent point mutations in exon 5, 7, and 8 of human p53 gene.