Each management practice (e.g. thinning and final cut) is described through quantifiable country-defined "operational criteria" (e.g., age, diameter or volume at which thinning or final harvest occurs) representing the most plausible estimate of the practices applied during the RP.
We infer that an average duration of approximately 3 years of smear-positive and smear-negative cases combined would seem the most plausible estimate.
19 Selecting a power of 90%, and the most plausible estimate of fixation failure rate (30%) and an intermediate value for the minimum clinically important ARR of 20% gives a treatment group size of 82.
Such mechanisms are not needed if either our most plausible mutation rate estimates are too high or the Amazon molly is younger than current age estimates suggest (effective U sdm = 0.04 – 0.9; T age = 40,000 – 100,000 years, see section 'Age...'..... below and [ 11, 12]).
We suggest that model 3 is the most plausible because it estimates the TMRCAs from the molecular divergence age of human and chimpanzee and without the preliminary divergence date of the modern human and Neanderthal mtDNAs.
Depending on the method applied, molecular clock approaches estimate the onset of the Malili Lakes radiation to 5.2-17.4 My, but the youngest estimate appears by far the most plausible, given the estimated timeframe for Sulawesi's final amalgamation (see above).
