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The upstream nodes including TGF-beta signaling pathway and cytokine-cytokine receptor interaction are most perturbed at the early stage.
Focal adhesion and ECM-receptor interaction are most perturbed at 10d.
Downstream nodes including focal adhesion and ECM-receptor interaction are most perturbed at the late stage.
Midstream nodes including MAPK signaling and p53 signaling are most perturbed at the middle stage.
The Jak-STAT signaling pathway, MAPK signaling pathway and p53 signaling pathway are most perturbed at 24h.
The TGF-beta signaling pathway, Cytokine-cytokine receptor interaction, and Wnt signaling pathway are most perturbed at 8h.
Similar(53)
The method described previously [ 78], for which an implementation is available http://github.com/ajmazurie/xstats.enrichment, was then used to evaluate how enriched the top of each list (i.e., the most perturbed genes at each time point) was in any of the functional categories listed.
First, TGF-beta signaling pathway is the top significant pathway (compared to other pathways) at 8h and is most perturbed (compared to itself at other time points) also at 8h.
Second, focal adhesion is the most significant pathway (compared to other pathways) after 24h and is most perturbed (compared to itself at other time points) at 10 days.
But it will not still the fears of those most perturbed by what is happening to the creativity cluster at the heart of the capital, whose main avenue Denmark Street has been for a century.
But it is the banks that are most perturbed.
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