Sentence examples for most penetrant phenotypes from inspiring English sources

We isolated one new recessive allele of plk-1, or683 ts, which appears to only partially reduce gene function as the most penetrant phenotypes we observed at the restrictive temperature were mis-oriented (transverse) P0 spindles and binucleate cells at the two-cell stage (Figure 8).

The most penetrant phenotype involves the sacrum of all mutant mice.

The most penetrant phenotype was staining in the posterior diencephalon with 94% (p<10−10, n = 17) and 81% (p<10−10, n = 16) of embryos showing this pattern with the chicken (Figure 3d) and human (Figure 3e) elements, respectively.

From this point on, we used Myo19-03 as the representative siRNA for our experiments, as it had the most penetrant phenotype.

Several of the most penetrant RNAi phenotypes are caused by single enzymes that are part of multimember families, for example, ceramide synthases (six enzymes) or neutral sphingomyelinases (four enzymes in mammals).

Of interest, the most highly penetrant phenotype in transgenic mice was inflammation in the nerve ganglia associated with interlobular neurovascular bundles in transgenic mice over a year of age (Figures 3C and 3D).

As previously mentioned, the FVB-MetM1248T/L1193V mice had the most penetrant mammary tumorigenic phenotype (Table 2).

When assessing net benefit of screening, a SER must consider all downstream harms and benefits and take into account the effects, not just of learning about the most penetrant or most clinically actionable phenotype, but also the impact of other associated phenotypes.

Of all the phenotypes associated with Ccnd1−/− mice, the most penetrant and dramatic is improper development of the retina.

This is consistent with the incompletely penetrant phenotypes observed, particularly recurrent unilateral eye defects and craniofacial malformations.

In contrast, Mendelian diseases demonstrate more predictable heritability patterns and often represent highly penetrant phenotypes.