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In contrast, in most patient samples IPS1 migrated as a full-length protein (Figure 1C, results not shown).
When added to EOC cultures, IL-12 alone had only minor effects on the proliferation or function of CD8+ T cells in most patient samples (Fig. 1B).
While ascites fluid had variable effects on CD8+ and CD4+ T-cell proliferation, it inhibited T-cell function in most patient samples, with CD107a, IFN-γ, and CCL4 showing the greatest inhibition.
By contrast, IL-2 had little effect on the expression of CD107a, CCL4, IFN-γ, or IL-2 for most patient samples, although it caused a weak but statistically significant enhancement of TNF-α expression (Fig. 1B).
Most patient samples that reacted in the CHIKV IgM ELISA were ONNV upon confirmatory testing in the PRNT (Table 3).
Although the human-to-mouse xenograft is the most commonly used in-vivo system for studying leukaemia and myeloma, most patient samples do not adequately engraft in immune-deficient mice.
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In most NR patient samples Jak/Stat signaling was elevated in a cell subpopulation in response to multiple cytokines (right hand side of heat-map in Figure 2A), whereas cells of most CR patients were largely non-responsive (grouped towards the left hand side of the heat-map in Figure 2A).
In most cases, patient samples have been limited to surgical specimens and peripheral blood collected over time.
For most patients the samples were taken at the same time of the day.
b IMD Index of Multiple Deprivation We then restricted analysis to the most recent patient sample from 2011/12.
For most patients, multiple samples were obtained at sequential times covering the acute, convalescent, and recovered phase of the disease.
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