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Exact(6)
Indeed, for most parameter sets the proportion of CI overestimates increases with higher n, as the sampling distribution narrows around the biased value.
When analyzing the robustness of the observed chaoticity against parameter changes for two illustrative current injection levels, we observed that the typical behavior of chaoticity or non-chaoticity is preserved for most parameter sets but interspersed are sets leading to different behavior.
As a consequence most parameter sets (57.5%) do not fall into any of the defined categories (Additional file 3, Fig. S5A, black sets).
Even for the short loop (n = 3 ), the differences between the full and semi-analytical solutions are less than an order of magnitude for most parameter sets.
Differences in simulation results for a pair that are consistent under most parameter sets are detected as TPEs (step 4 in Figure 2).
We observed that for most parameter sets the models showed too strong phenotypes for the double mutants, and after the validation only 118 (loss-of-signal) and 531 (interference) parameter sets remained.
Similar(54)
This approach was useful to simulate the uncertainties in the values of salinities for the entire period and to determine the most probable parameter sets for which the observed values were closer to the modelled values.
Notably, most identified parameter sets are located in a biologically meaningful region.
We use the minimum coefficients of variation as robustness measure in order to be able to compare the robustness of most favourable parameter sets.
An extensive parameter survey was then conducted to choose the most suitable parameter set.
The most probable parameter set from the grid search is shown in Table 2.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com