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The first generation of inhibitors are multi-targeting ATP competitive inhibitors, with most originally developed as VEGFR inhibitors that also inhibit the FGFRs due to similarity in the ATP binding pocket structure.
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A number of computational methods have been employed for that purpose, although most were originally developed to distinguish disease-related nonsynonymous single nucleotide variants (nsSNVs) from polymorphisms.
In most cases services were originally developed for the expatriate colonialists and extended in the course of time to local residents.
BMI, the second most influential factor, was originally developed to measure obesity in humans (23).
Note that most tracking methods are originally developed for single-object tracking, but extendable for multiple-object tracking.
A large number of MST methods are being researched, most of which were originally developed to trace fecal bacteria in natural waters.
Most of the drugs originally developed and marketed as antide pressants have also been found to be effective in one or more of the anxiety disorders, although all do not have US FDA-approved indications for the latter.
While various NGS assemblers can use information from several libraries of read-pairs, most of them were originally developed for a single library and do not fully benefit from multiple libraries.
Most of the procedures were originally developed to treat infertility or prevent genetic diseases.
Most of the schedules were originally developed for power plants but shortly after that the optimized scheduling was employed for mechanical components (Tsai et al. 2001) and then for production lines (Sortrakul et al. 2005).
The most common model equations were originally developed in the 1950s at the University of Minnesota, and in the special case when the circumferential stress is zero, have come to be known as the natural shape equations.
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