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Most organisms contain multiple members of the Hsp70 family in virtually all cellular compartments [11].
Most organisms contain single copy Arp genes, with the exception of E. histolytica, which has two genes that encode an Arp5 [41].
Most organisms contain at least three Pex11 protein family members (see Table 2).
In contrast, most organisms contain several rpf-like genes, whose products are functionally redundant [ 3, 6- 8].
Thus, although there are exceptions (see below), centromere regions from most organisms contain repetitive sequences, suggesting that those sequences contribute to important aspects of centromere function.
Most organisms contain multiple Wnt genes which initiate distinct cellular pathways, namely the canonical Wnt/β-catenin pathway, the planar cell polarity pathway, or the Wnt/calcium pathway.
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In most organisms containing MEP pathway homologs, the genes encoding ispD and ispF are neighbors on the chromosome with the ispE at a distal location.
COG0523 is widespread in eukaryotes, with most organisms containing one to four homologs (see 'G3E'subsystem), and have been associated with stress phenotypes (see Table 2 and Additional File 1).
While vertebrates have 10 paralogs, most other organisms contain three or four anoctamin family members.
Most organisms usually contain several hundred tRNA genes distributed randomly over their entire genome.
Most organisms that contain one or more subfamily III proteins also have retained one or more subfamily IV proteins, so while they are similar in some sense (and likely arise from the duplication of a single primordial gene), it is doubtful that their functions are completely overlapping.
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