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The goal of most ongoing studies is to identify drugs able to affect CSCs biology, either inducing selective toxicity or differentiating this tumor cell population into nontumorigenic cells.
Therefore, in most ongoing studies of oncolytic reovirus, the state of activation of the EGFR/Ras axis is not used as an entry requirement or as a stratification factor.
Among the drugs that had the most ongoing studies were also two anti-hystamine drugs, ketotifen and bepotastine, and the antibacterial moxifloxacin: these were tested in 3 RCTs each for the treatment of allergic or bacterial conjunctivitis in children.
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However, most ongoing clinical studies are in a preliminary stage, and there is yet no evidence that they will prove to be effective.
This means the IUCN Red List, the most sophisticated ongoing study of its kind, monitors less than 1% of world species.
Finally, most ongoing CV outcome studies have been designed to test the drug versus placebo on top of standard of care.
These ongoing studies, most of which are still recruiting and have small numbers of patients, report promising results with response rates of over 50%.
Currently, there are few applications in medicine but numerous ongoing studies will most likely result in novel use in the future.
No data are available on long-term efficacy and safety and, most importantly, no ongoing study has been designed to collect data on hard outcomes (smoking-related cancer, major cardiovascular events and chronic obstructive pulmonary disease – COPD) over a long follow-up period [ 11, 24].
Analyses requiring a locked database relied upon the most recent interim datalock of the ongoing studies, which occurred on 30 April 2008, and which includes 29 PDSS events.
Ongoing studies have to establish the most efficient imaging strategies for (the different subtypes of) malignant lymphoma.
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CEO of Professional Science Editing for Scientists @ prosciediting.com