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The constraint (5) means that each base x i can be paired with at most one base.
Constraints (6) and (7) mean that each base can be paired with at most one base regardless of whether the base pair is formed inside or outside the sequence (Fig. 4a).
A secondary structure B is a set of base pairs B={ i, i′) | 1≤ i< i′≤| S|} over S, where each base takes part in at most one base pair.
We assume that each base can be paired with at most one base regardless of whether the base pair is formed inside or outside the sequence, and internal pseudoknots and crossing interactions (external pseudoknots) are disallowed.
The Vienna RNA Package currently implements three different models for handling the dangling-end contributions: They can be (a) ignored, (b) taken into account for every combination of adjacent bases and base pairs, or (c) a more complex model can be used in which the unpaired base can stack with at most one base pair.
For example, the original Illumina pipeline produced quality scores in the range of −40 to 40, with at most one base at each position receiving a score of ≥ 0. The precise meaning of quality scores depends on the base-calling method, and it is not desirable for mapping methods to be too closely coupled to any particular base caller.
Similar(54)
In an RNA secondary structure, each base interacts with at most one other base, and no base pairs cross each other.
For the target search, we defined an interaction seed of eight paired bases and at most one unpaired base within the aforementioned conserved Yfr1 motif (I ntaRNA parameters -p 8 -u 1 -f 17,27).
This has at most one fewer base pair matching and is a valid solution for the subsequence (i + 1, j) with a larger value than its current value, contradicting the optimality of D(i + 1, j).
This approach seems the most adequate one based on the present and on published data, at least until convincing evidence is provided in favour of a stratified approach in which patients are assigned to different treatments according to the extent of their medical needs.
Moreover, our framework allows us to discriminate amongst alternative updates of action domain descriptions and to single out a most preferable one, based on a given preference relation possibly dependent on the specified criteria.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com