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Distances calculated for both plastid and nuclear-encoded proteins using the Dayhoff and VT substitution matrices were larger than the average number of substitutions (i.e. calculated without substitution matrix), which shows that amino acids were most often substituted with similar residues, suggesting functional conservation.
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Except where there is a designated hitter, the pinch hitter most often substitutes for the usually weak-hitting pitcher.
Although an arginine is the most prevalent amino acid at this position it is often substituted by a lysine or a proline.
In the movies, Blofeld, for obvious political reasons is often substituted for the Russian government (i.e., From Russia With Love) as the evil genius behind most of Bond's most difficult assignments.
On Saturday he often substituted raw power for supple lyricism.
However, the amino acids were often substituted in other domains.
These days, minor leaguers perhaps work most often as substitute teachers and, naturally, youth baseball instructors.
Asp and Glu are negatively charged and often substitute each other, and most globular proteins have negative charges on their surface.
Portuguese texters often substitute "m" for the tilde.
The guitarist Dean Brown seemed equally unsettled in his solo forays, often substituting velocity for coherence.
Empiricism must often substitute for first principles.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com