Sentence examples for most often mutated from inspiring English sources

The TP53 tumor suppressor gene has proven to be one of the cellular genes most often mutated in human neoplasias.

Consistent with its prominent role as a MEK kinase, B-Raf is the component of the ERK pathway most often mutated in human tumours, with a particularly high frequency (43%) in human melanoma.

TP53 is the gene most often mutated in human cancer, and several studies have shown that loss of one allele in the germ line leads not only to a much increased risk of cancer but also to a decreased AR in lymphoid cells from both rodents (Clarke et al, 1993; Lowe et al, 1993) and humans (Camplejohn et al, 1995, 2000).

Overall, the prevalence of mutations is much higher in mitochondrial aaRSs, and the two most often mutated aaRSs are mitochondrial glutamyl-tRNA synthetase and dual localized glycyl-tRNA synthetase.

Most frequently mutated was PIGA, with seven mutations.

Therefore, mutation studies have been often restricted to sequence analyses of the two most frequently mutated genes— LRRK2 and parkin and sometimes even further restricted to sequences coding for functional domains within these genes.

Unsurprisingly, TP53 was the most frequently mutated tumour suppressor gene with >40% of patients harbouring a missense or truncating mutation.

Tumor suppressor gene p53 (MIM 191170) is the most frequently mutated gene in human cancer.

The HVEM (TNFRSF14) receptor gene is among the most frequently mutated genes in germinal center lymphomas.

The most frequently mutated gene is MYBPC3, encoding cardiac myosin-binding protein-C (cMyBP-C).

Although recent cancer genomics studies have identified a large number of genes that were mutated in human cancers, p53 remains as the most frequently mutated gene.