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Like most of the alignment algorithms in the literature, the one proposed in this work is based on the dynamic programming approach.
Most of the alignment based methods we discussed discover motifs based on both sequence and structure similarity.
The average branch length for most of the alignment was 0.1 but each dataset contains a 100 bp region where the average length is increased to 1.0.
Although most of the alignment boundaries were within 10 residues of the embedded domain boundaries (71% BLASTP, 75% SSEARCH), BLASTP and SSEARCH also created incorrect alignment boundaries.
The posterior probabilities are close to 1 for Topology 1 for most of the alignment and we see an obvious change in probability at the appropriate points giving us high confidence in the ability of the method to predict the changepoints.
Among the various kinds of motifs considered in literature, one would ideally want patterns to capture a combination of sequence and structure similarity which in a sense is captured by stochastic methods like CMfinder and RNAPromo and most of the alignment methods.
Similar(54)
Of the 186 TEI 171 could be aligned to 3 or more reads and most of the alignments are highly consistent in their breakpoint position, with variation close to null.
Most of the alignments showed a similitude between 75 and 90%% (Additional file 4B).
Moreover, most of the alignments could easily be clustered by eye into larger groups for which the specifier codon remained directly apparent from the alignment.
Most of the alignments between the linkage map and the Arabidopsis genome sequence are consistent with previously identified collinearity blocks [ 27, 28].
This alignment updated the initial version of the B. rapa linkage map [ 16]. aBlocks expanded compared to the previous reports [ 27, 28] Most of the alignments between the linkage map and the Arabidopsis genome sequence were consistent with collinearity blocks previously inferred using sequenced markers with homology to single Arabidopsis genes [ 27, 28].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com