Most of genes involved in the flavonoid biosynthesis pathway have been characterized and functionally expressed in recombinant microorganisms.
After the HAECs were incubated with 0.02 mg/ml of DMSA-Fe2O3 for 24 h, the expressions of most of genes involved in the apoptosis cascade and calcium-handling proteins were changed from 0.5- to 1.5-fold compared to those of HAECs without DMSA-Fe2O3 treatment, except MAPK14 (mitogen-activated protein kinase 14, MAPK14, also called p38-α), CASP3 (caspase 3), and BCL2 (Bcl-2).
Most of genes in PCoA dense region in Figure 2 are core genes.
Overall most of genes were commonly regulated with the ERβ-selective compounds (Table 2).
Our results indicated that most of genes investigated had results congruent between microarray and RT-PCR assays (Table 4).
While most of genes coding for chaperone proteins are generally underexpressed, Hsp90 could be activated via HemE [45].
Most of genes coding for the proteasome apparatus were induced after the early stage, promoting the degradation of overloaded unfolded/misfolded proteins resulting from ER stress/UPR.
Most of genes in the pathways showed a co-expression pattern, some of which were members of conserved co-expression clusters (Tables 1 and S1, Figure S2).
Apoptosis mechanisms pathway displayed the most of genes expressions changes, which were 35 genes were up-regulated and 33 genes wee down-regulated (Figure 6).
We found that most of genes, receptors, co-receptors, and target genes expressions were increased in HB1.F3, but that of Wnt inhibitor was increased in F3.Olig2.
We further investigated the transcription regulatory network operating at these genes and identified that most of genes closely interact with ID2, which encodes for a helix-loop-helix inhibitor of DNA binding.
