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The most obvious endpoint for treatment failure in patients with IgAN is progression to ESRD.
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The most obvious explanation for such failure is that the intervention concerned is not actually efficacious with respect to the endpoint being studied, i.e., calcium and vitamin D have little to do with the risk of the diseases concerned.
As a matter of fact, it is most likely that evolutionary history will be misconstrued as representing a progressive "main line" when there is only one obvious endpoint available.
The most obvious is security.
The most obvious is piracy.
The most obvious is competence.
The most obvious is location.
The most obvious is income.
But by this time Scholem had long ago made his way to Jerusalem, the obvious endpoint of his Zionist dream.
The most obvious is conflicts of interest.
The most obvious was his shooting.
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