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The other most notable pathway that was obviated by our analysis relates to the significant impact that A20 had on cell cycle in hepatocytes.
The second pathway, ECM-receptor interaction, was previously discussed because it was the most notable pathway in breast cancer.
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Furthermore, ECM remodeling appeared to be the primary pathway regulated by vitamin C. Other than GPRIN3, the most notable gene in this pathway is TIMP metallopeptidase inhibitor 3 (TIMP-3).
The most notable property of the pathway interaction networks for the glucose response at t = 2 is the high centrality of the Cytokine pathway.
The most notable outlier is the Tat pathway.
The activation of this pathway is most notable in cancers that have either inactivating mutations of the PTEN gene (e.g. glioblastoma, melanoma, prostate cancer and endometrial carcinomas) or overexpression of an activated member of the epidermal growth factor (EGF) receptor family (e.g. Her2/neu in breast cancer) (Luo et al, 2005).
The most notable variation was in the biosynthesis pathways of cofactors, prosthetic groups, electron carriers as well as nucleotides and nucleosides.
Most notable among these is the NOTCH cell signal pathway.
Most notable, the identification of p53 tumor suppressor gene pathway in medulloblastoma transcription factor interactomes is consistent with known p53 upstream and downstream mutations in many cancers, a central mechanism in the mutagenesis of cancer cells.
Most notable among these were genes associated with the extrinsic pathway of apoptosis.
Perhaps the most notable feature among the genomic islands is the urea pathway genes located on GI-4.
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