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The most notable pathological aspect of PD is the loss of the nigrostriatal pathway and, more precisely, of the dopaminergic neurons in the substantia nigra (SN).
For example, Desouky et al. [ 45] reported extensive ultrastructural alterations to hepatopancreas epithelial cells, the most notable pathological features including vacuolation, degradation, and distinct cell lysis in red swamp crayfish following acute exposure with insecticide ethion (0.36 mg L−1).
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However all of these mouse models had shortcomings, of which the most notable is failure to exhibit degeneration of the nigrostriatal system, a key pathological feature of PD (Manning-Bog & Langston 2007).
Cirrhosis, the most advanced stage of fibrosis, includes inflammation as a pathological factor but this aspect is remarkably reduced in fibrosis, with septa and nodule formation being the most notable features [ 2].
The most notable event?
The most notable is Carafe.
The most notable absence?
The most notable was Catherine Arnauld (1590 1651).
Here are four of the most notable.
Spain is the most notable example.
And the most notable event of 1625?
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com