The two most notable concerns were (1) that many of the statistical relationships were estimated based on a cohort of patients with established RA, and (2) that extrapolating efficacy data from such a patient population could underestimate the benefit of more aggressive early treatment.
One of the most notable concerns voiced by nurses at two of the hospitals was the presence of a dual or hybrid system in which some physicians were placing orders within the CPOE system, while others were still writing paper orders.
The most notable concerned Desargues's theorem.
The most notable features concern searching and tagging.
Its most notable failure concerned the land itself.
In fact, the most notable moment concerning Gold Star families in last year's conventions came at the Democratic gathering, when Khizr Khan, whose son Humayun was killed in Iraq, spoke out against Trump.
The most notable development concerning the Yankees on Tuesday night did not occur in the Bronx, or on a baseball field, or even in a training room, as so often has been their fate this season.
In the United States the most notable deals concerned Washington state's Puget Sound Energy, which was taken private by Macquarie Group for $6.1 billion, and the Texas utilities firm TXU, which was acquired by a group of private equity firms that included Texas Pacific Group and Kohlberg Kravis Roberts & Co.
The most notable change concerns apoplexy (brain stroke), which moved from a rank of 33 to 29 and then to 23 over the three rounds.
Of note, the difference in gene up-regulation between donor A and other blood samples included many genes involved in amino acid, purine-pyrimidine, and central intermediary metabolism, and the most notable difference concerned genes contributing to carbohydrate metabolism (Fig. 3, and see below).
