Sentence examples for most normal tissue from inspiring English sources

While enzymes regulating lipid synthesis are often expressed in low levels in most normal tissue (Clarke, 1993), they are overexpressed in multiple types of cancers.

Tumor tissue with lower oxidative reduction (redox) potential relative to most normal tissue could increase reductive activation of these quinone derivatives in the tumor [ 2].

The use of LET (alpha) particle emitting radionuclides has the advantage of high cytotoxic potency, combined with a low range and thus not reaching most normal tissue surrounding the tumor.

Lysophosphatidic acid acyltransferase beta, which normally is expressed in low levels in most normal tissues, may not be necessary for survival of these normal cells, but the malignant cells may be more dependent on its activity.

Because most normal tissues express an isoform of pyruvate kinase other than PKM2, selective targeting of PKM2 provides an opportunity to target cell metabolism for cancer therapy.

It has two forms, COX-1, which is found in most normal tissues, and COX-2, which is induced in the presence of inflammation.

Tumor hypoxia refers to the development of regions within solid tumors in which the oxygen concentration is lower (0 3%) compared to that in most normal tissues (4 9%) (Vaupel and Hockel, 2000).

The accessibility and abundance of EDA in majority of the tumors and its absence in most normal tissues has made EDA a useful target for therapeutic intervention that has led to the development of IST-9 antibody that selectively blocks EDA accessibility to integrins and thus prevents metastasis.

A low uptake of radioactivity was noted in most normal tissues except for the bones.

Generally, COX-2 is not detectable in most normal tissues, but it is induced by pro-inflammatory cytokines, growth factors and carcinogens.

Up-regulation of hypoxia-inducing factor-1 (HIF-1) occurs in the majority of primary malignant tumors and in two-thirds of metastases, while most normal tissues are negative.