Exact(2)
Most new anticancer drugs are prohibitively expensive not only for millions of patients from developing countries, but also for many patients without strong medical insurance in developed countries.
It is beyond the scope of this paper to discuss the degree of innovation for new drugs and/or to make a cost analysis, as it has already been pointed out that the approval of most new anticancer drugs by EMEA offers no substantial advantages and puts further burdens on national health services (Garattini and Bertele', 2002).
Similar(58)
High level officials at the National Cancer Institute (NCI -- characteristically cautious and tempered--are calling taxol the most exciting new anticancer drug in 15 to 20 years.
Histone deacetylase inhibitors are considered among the most promising new anticancer drugs, and several agents have recently entered clinical trials.
Both in vitro and in vivo data and ongoing clinical trials have recently revealed that HDACIs could be used against different solid tumors and hematological malignancies, consisting one of the most promising classes of new anticancer agents [ 8– 13].
For the evaluation of effect in animal studies during preclinical development of new anticancer agents, reduction in tumor volume is the most commonly used criterion for efficacy.
One of the most important research directions in bioinorganic and medicinal chemistry is dedicated to the development of new anticancer compounds with the potential to be used either in monotherapy or in combination therapy with other approved anticancer drugs as chemosensitizers [1].
Studying drugs' cellular uptake, intracellular distribution, and intracellular interaction with target molecules at the single-cell level (the most fundamental units at which drugs take effect) are important issues for the development of new anticancer drugs.
There are currently an estimated 800 new anticancer agents in clinical development [ 5], making it impossible to test most new drugs in more than a minority of situations where they might be useful [ 6].
Brazilian flora, the most diverse in the world, is an interesting spot to prospect for new chemical leads, being an important source of new anticancer drugs.
Mottamal, M., Zheng, S., Huang, T.L. & Wang, G. Histone deacetylase inhibitors in clinical studies as templates for new anticancer agents.
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