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Owing to the formation on its surface of an oxide film that is relatively inert chemically, it has excellent corrosion resistance in most natural environments.
Most natural environments are relatively mild, and therefore most P450s have not been selected in Nature for the ability to withstand temperatures above ~ 40 °C, yet industrial processes frequently require extended incubations at much higher temperatures.
Copper is one of the most ancient metals of human civilization, and a trace metal in most natural environments, posing no serious threat to biota and vegetation at its background levels.
It has been documented that nitrite reductase encoded by nirS was predominate as compared with nirK in most natural environments (Bothe et al. 2000), while it seemed that nirK gene was more dominant in composting systems (Wang et al. 2013).
However, in most natural environments, the availability of food tends to fluctuate.
It readily reacts with organic compounds, further complicating its chemistry in most natural environments.
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