Sentence examples for most mutations with from inspiring English sources

The prediction that large increases in mutation rate cause major reductions in fitness is based on the supposition that most mutations with fitness effects are deleterious and that the effects of these deleterious mutations are either additive or negatively synergistic.

Fortunately, such regions are relatively uncommon, and CGS appears to detect most mutations with a reasonable degree of confidence.

So, in theory, it would seem that most mutations with strong potential to affect DNA flexibility would be less likely to alter amino acid sequences of proteins.

Third, most TE insertions are in themselves probably neutral, as are most mutations, with some deleterious insertions that are ultimately eliminated, and occasional beneficial insertions that are eventually fixed.

If adaptation is seen as a fine tuning of genotypes to their environment, an important intuition is that, within a well-adapted population, most mutations with detectable fitness effects tend to be deleterious.

The tapetum adjacent to the sporogenous cells plays a crucial role in supplying nutrients to microsporocytes and providing their release form tetrads. Therefore most mutations with defects in the tapetum cause male sterility.

There have been few genome-wide association studies on SNHL [ 5, 6], and most mutations associated with SNHL have been SNVs (http://deafnessvariationdatabase.com).com

ORF1 of CaHEV contained most mutations compared with prototype avian HEV (prototype aHEV); 5, 16, and 29 nonsilent mutations occurred in the methyltransferase, helicase, and RNA-dependent RNA polymerase (RdRp) functional domains, respectively (data not shown).

This pattern is consistent with a birth-and-death model where most mutations go extinct with only very few ancestral polymorphisms surviving to become dominant [ 67].

Likewise, TP53 is mutated in 30 60% of IBCs, with most mutations located in exons 5 8, the mutational hot-spot of TP53 [ 17, 25- 27].

Although most mutations are neutral with no effect on fitness or harmful, some mutations have a small, positive effect on fitness and these variants are the raw materials for gradualistic adaptive evolution.