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Mutations are genetic mistakes, and the ones found in this research were not inborn, but developed later in life, like most mutations that cause cancer.
Most mutations that were predicted to disrupt the secondary structures fail to replicate, while compensatory mutations were allowed replication to resume.
To date, most mutations that have been reported in LGMD patients have been point mutations, and these lie in approximately 17 genes.
Since most mutations that confer resistance are linked to an impairment of viral RC, this type of association was expected.
Also, most mutations that have been associated with resistance of FMDV to GU are A→G transitions, and they could have been favored by the presence of FU in the FUG combination.
Most proteins show an ω well below 1, since most mutations that lead to amino acid substitutions decrease fitness and hence are unlikely to become fixed between species (purifying selection).
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Our observations indicate that most ubiquitin mutations that disrupt E1 activation also disrupt other functions.
Because most random mutations that affect intelligence will reduce it, evolution will tend to select against them.
Over the years, he and his team have defined the mechanisms of the most frequent mutations that lead normal immune cells to transform into lymphoma.
Most OFD1 mutations that have been identified in individuals result in a truncated, non-functional protein (Thauvin-Robinet et al., 2006).
Our genotyping panel included most gene mutations that are targeted by new drugs in ongoing clinical trials.
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