Sentence examples for most mutations resulted from inspiring English sources

This fact was confirmed by nucleotide sequencing which also demonstrated that most mutations resulted in amino acid substitutions.

Most mutations resulted in a significantly lower Tm values, although R269C showed a significantly higher Tm (38.6 ± 0.2 °C) than the wild type (Table S4 of the Supporting Information).

Most mutations result in a truncated protein and only a few inactivating missense mutations have been reported.

Interestingly, most sltA mutations resulted in truncated versions of the SltA transcription factor, mirroring the results of Calcagno-Pizarelli et al. (2011).

Most of the mutations resulted from dramatic population booms, they suggest.

Expression of most of the mutations resulted in morphological changes in MCF10A cells in 3D acinar culture, differentially promoted cell invasion, and activated p-AKT and p70-S6K in the absence of EGF stimulation [ 43].

Most missense mutations result in misfolding of PAH, increased protein turnover, and a loss of enzymatic function.

To explore RNA interference (RNAi) as a potential therapy for UCMD, we designed a series of small interfering RNA (siRNA) oligos that specifically target the most common mutations resulting in skipping of exon 16 in the COL6A3 gene and tested them in UCMD-derived dermal fibroblasts.

Initial studies demonstrated that most SI mutations result in lack of enzyme protein (i.e. null mutation) [ 26].

Most such mutations result from replication slippage that escaped the proofreading activity of mismatch repair systems [ 3].

By contrast, in LS, the most common mutations result in reduced catalytic activity (Hanna et al., 2006; Kontaridis et al., 2006; Tartaglia et al., 2006).