One study of breast cancer patients found most mutations were present in fewer than 5% of patients.
In other words, the most framshift mutations present in our study were generally not phase-variation expression genes.
Even for PD itself, this assessment is not straightforward as most mutation reports present fragmented data on only one or few PD genes.
Activating RAS mutations, including KRAS, are the most frequent oncogenic mutations present in human tumors, detected in about 20% of non-small-cell lung cancer (NSCLC), 40% of CRC and over 90% of PAC [19].
Most disease-causing mutations present in autoimmune lymphoproliferative syndrome patients reside in the DD of CD95, resulting in an inability to bind FADD and form a DISC.
In the event of late-breastfeeding transmission, Y188C/H was the most common mutation present and was found at similar frequencies for infants in the SWEN and SD-NVP groups (50% of 4 vs. 50% of 8; p = 1.00; Table 2).
To represent genotypes relevant to melanoma we selected melanoma cell line pairs that harbor the V600E BRAF mutation, the most common mutation present in melanoma (Wellbrock and Hurlstone, 2010), but differ in their expression of MITF, and as a consequence the individual cell lines are either inherently invasive (MITFlow) or poorly invasive (MITFhigh).
It is interesting to note that the third most prevalent mutation (present in 39 of 332 INHR isolates or 12%) at inhA promoter position -8 appeared to have little diagnostic significance in our isolates as they always co-occurred with katG315.
We extracted the variants from the extended ouput by ignoring some or all of the following filters: dbSNP filter (most mutations in NA12878 are present in dbSNP), clustered position filter (because the reads are a product of amplicon sequencing), contamination, and fstar LOD.
Most of the solubility enhancing mutations present in XRAY2-2K3A are in close proximity to the multimer interfaces observed in that crystal (not shown), suggesting that these mutations may have affected the crystal packing.
