Sentence examples for most mutations do from inspiring English sources

First, natural selection may have shaped TEV UTRUTR folding to be robust to mutational changes and, therefore, most mutations do not have an strong effect on RNA folding simply because they have no major effect on the structure [ 44].

This means that most mutations do not improve fitness: There are many more ways of making things worse than of making them better.

Our results analysing some of the properties of the 41 PD-associated forms of LRRK2 emphasize that most mutations do not exert their effects in the same way as the G2019S mutation by simply increasing catalytic activity.

For an evolving protein under selection for stability, there are three distinct regimes for d N/d S, and these three regimes are obtained in our simulations as well: First, at high stabilities, most mutations do not have a selective advantage/disadvantage.

At higher folding stabilities, most mutations do not have a significant effect on d N/d S. For Mb with Δ G = −9 kcal/mol, d N/d S is only altered by mutations having ΔΔ G > 4 kcal/mol which have a probability of occurrence < 0.04 (supplementary fig. S4, Supplementary Material online).

It is unlikely that this situation can be generalized to other Mb mutants, as the redox potential of the Mb mutants is not far from wild-type Mb values and most mutations do not yield deviations from wild-type Mb autoxidation rates as large as those of the E7 mutants (Table 5).

As can be seen in Figure 7, most mutations did not significantly reduce the inhibition of podosome formation compared to control, as dystroglycan-GFP carrying these mutations still had a dominant-negative effect.

Whereas most mutations did not significantly interfere with Myr-59 binding or HDV infection, alteration of five residues of hNTCP between aa 157 165 and its monkey counterpart (from KGI VISLV L to GRI ILSLV P, distinct residues are underlined) completely abolished Myr-59 binding and the ability to support HDV infection.

Given the repetitive nature of the Dumpy protein, i.e. all the EGF-DPY-EGF motifs, perhaps most missense mutations don't produce a visible phenotype.

The majority of these genes have at least one transcript unaffected by the PTC, suggesting that most PTC mutations do not switch off the gene, but rather a specific transcript.

He explained that like all RNA viruses, the one that causes Ebola makes a lot of mistakes when it copies itself, but most of these mutations do nothing.