Sentence examples for most mutations arise from inspiring English sources

The MECP2 gene has some unique characteristics: (1) it is mainly affected by de novo mutations, due to recurrent independent mutational events in a defined "hot spot" regions or positions; (2) complex mutational events along a single allele are frequently found in this gene; (3) most mutations arise on paternal X chromosome.

In the tetraploid genome of MB101, only 7% of genome-wide mutations are ∼50% heterozygous i.e., present before tetraploidy occurred indicating that most mutations arise after tetraploidy.

The matter remains unsolved, but there is clear evidence for a leading role of DNA replication on base-substitution mutations: despite its proof-reading function, most mutations arise from DNA polymerase errors (Drake et al. 1998; Lynch et al. 2006).

Most mutations arise spontaneously (de novo) in the paternal germ line; thus, individuals with RTT are typically females who, owing to X-chromosome inactivation, are somatic mosaics for normal and mutant MECP2.

The finding that most spontaneous mutations arise on paternal X-chromosome supports the higher contribution of replication-mediated mechanism of mutagenesis.

Because most new mutations arise when the population is large, selection within the colony is minimal.

Although therapeutic targeting of tumour-associated mutations may be effective in tumour management, most tumour mutations arise as later stage epiphenomena of tissue disorganisation and their involvement with tumour initiation, promotion, or progression has not been conclusively established (Sonnenschein and Soto, 1999, 2000; Seyfried, 2001; Bergstein, 2003).

Most of these de novo mutations arise on the paternal × chromosome [ 45, 46], increasing in frequency with paternal age, which is consistent with the hypothesis that point mutations occur more frequently during spermatogenesis than oogenesis.

Because reverse transcriptase lacks the "proofreading" function that most DNA-synthesizing enzymes have, many mutations arise as the virus replicates, further hindering the ability of the immune system to combat the virus.

Although our mutant strains were selected or chosen for specific phenotypes and therefore bias may occur for the causative mutation, most of the mutations arising throughout the genome will be random mutations unrelated to the observed phenotypes.

While it is possible that some of those lying outside recombined regions may have been present prior to recombination, we propose that most of these mutations arose in the period of rapid pseudogene accumulation after recombination.