Most mutations occur when DNA divides.
Most mutations have no effect.
Mutations are genetic mistakes, and the ones found in this research were not inborn, but developed later in life, like most mutations that cause cancer.
Although most mutations are deleterious, the exceptions are the raw material of evolution.
And most mutations suggest a propensity, not a guarantee, for a disease.
People with any one of several mutations in the gene -- most mutations are the switch of a single base for another -- grow old prematurely and may die of old age in their teens.
Most mutations happened in provinces in middle and western China.
Most mutations, including R882, occur within this tetramer interface.
These mutations act as hot spots for mutagens that cause DNA damage via different mechanisms.
Given the deleterious effects of most mutations, we would predict that increasing the mutation rate should generate progressively larger reductions in fitness, assuming that the mutations accumulate in the genome and that the effects of the mutations are additive or act synergistically [8].
