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Most mutants have a reduced fitness relative to the wildtype virus.
Studies of replicator dynamics on a neutral network often consider a very large value of q so that most mutants have d = 1 (e.g., [ 11]).
Preliminary screening for synthetic lethal interactions by SGA with a subset of actin alanine scan alleles used in this study against the 238 genes that have CHI interactions with act1 ∆, showed that most mutants have more synthetic lethal interactions than CHI interactions (C. Boone, personal communication).
However, Q e = Q + λ (1 - Q) is valid only if either (1) a neutral set is uniformly distributed over the genotype space [a neutral set is a set of genotypes where all genotypes map to the same phenotype], or (2) q is so large that most mutants have d = 1.
Similar(56)
At P14, most mutants had initiated hypertrophic chondrocyte development in the SOC (Fig. 5E, F).
Noteworthy, most mutants had altered susceptibility to multiple antibiotics, indicating that the development of resistance is not specific to a given antibiotic.
Most of the mutants have only been superficially studied.
Most L. lactis mutants have been constructed from strain MG1363 and its derivatives.
Tu et al. (32) reported that the C-terminal region of HBx is crucial to its transcriptional function and that, in tumor tissues, most HBx natural mutants have lost their capacity for controlling cell proliferation, viability and transformation.
Although most of the mutants have no detectable activity in our in vitro enzymatic assays, R207Q is active but with reduced allosteric kinetics compared to that of the wild-type enzyme.
Although lignin is a load-bearing polymer in the secondary cell wall, most lignin mutants had no obvious morphological phenotypes, despite a reduced lignin content.
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