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Visual inspection of the figures also suggests that STMN4 is the next monotonic gene in the list of four. Figure 7(C) indicates that ARID5B with SVDE = 2.03 is the third most monotonic gene.
Figure 7(B) shows that STMN4 with SVDE = 0.91 is the second most monotonic gene, because the expression values of two samples, one from Stage Three and another from Stage Four, are very close.
While there are some classes of subunit nonlinearities that could in principle cause cones to be missed in the STA calculation (e.g. full-wave rectification), in practice most monotonic nonlinearities, including half rectification, which appears to dominate in midget cell responses, will not do so.
Finally, with respect to changes in tuning characteristics (not illustrated in Fig. 4F for clarity), most non-monotonic ILD functions (61.1%) showed a decrease in tuning width, while there was an increase in the tuning dynamic range for most monotonic ILD functions (64.2%).
These preprocessing steps assume a linear model of the ganglion cell response, but linear analysis is adequate for the purpose of cone localization, because it only requires that each cone provides non-zero input to at least one ganglion cell, which will be true for most monotonic non-linearities; the same procedure was also anatomically validated in previous work (Field et al., 2010).
Figure 7(A) reveals that SOX6, with SVDE = 0.37, is the most monotonic gene compared to the other three genes in Figure 7, because its samples from different stages are well separated, except for a single discriminating error for Stage Four.
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Figure 4a shows the most likely monotonic change in allele frequencies at all eight non-Y loci when clines are traversed with respect to the consensus MLE orientation.
The positive trend for the pooled metals metric and ASD was highly significant and displayed the most regularly monotonic linear dose response of all exposures examined.
This parameterization approximates most smooth, monotonic saturating functions well enough that the qualitative behaviors we report below hold true even when p r is defined in a variety of other ways.
When all PFASs were simultaneously entered into the model, PFOA and PFNA levels were positively associated with ADHD, whereas negative associations with the other compounds persisted, with most showing monotonic trends.
Thus, while total soluble VEGF is theoretically the most isoform-monotonic signal, there may be no practical differences between it and matrix-bound VEGF.
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