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Most modules show good scaling behavior up to 4 or 8 threads, but show only moderate reduction in runtime when the number of threads is increased further.
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Most of the modules show enrichment for specific GO categories.
Most of the modules showed strong functional enrichment for particular Gene Ontology categories.
Figure 4 demonstrates that most gene co-expression modules showed some degree of preservation across hippocampus and striatum, with larger modules showing better preservation than smaller ones.
Most of the 15 modules showed extremely high levels of GO enrichment with GO categories enriched as much as 373 fold and p-values as low as 1.27e-22.
The fact that this order is kept in such a high percentage of the CRMs of so many motif modules shows that most likely there is an order between the binding sites of the two TFs BACH1 and AP-1, although there is no literature support this order yet.
We have observed two distinct expression patterns of lncRNAs in ID-gene-enriched modules, showing inverse relationships most noticeably with regard to the mid-to-late fetal period.
Most myositis patients showed coordinate overexpression across all modules (shown as an equilateral right pentagon in the radial plot; Figure 2B), but DM showed some heterogeneity of relative overexpression of the type 1 IFN module (i.e., cluster A).
Several modules showed patterns of expression that were most affected by the culture growth medium (heatmaps illustrating the expression profiles of all modules are provided in Additional file 3).
Beside the total number of enriched modules, we also counted the number of enriched modules among the top 50 distinct modules, showing that for each method that produced more than 50 modules, most of the high-ranking modules satisfy the enrichment threshold.
The module membership (MM) versus gene significance (GS) plots for these modules showed that MM and GS are highly correlated, indicating that genes most significantly associated with the trait are often also the most important (central) elements of the respective modules.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com