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Although most mitochondrial polymorphisms are believed to be neutral, population-specific mtDNAs may be functionally different and exert varying influences on the outcomes of diseases [7], [12] [14].
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The nonsynonymous A10398G (T114A) polymorphism in the ND3 (NADH dehydrogenase subunit) gene of the mitochondrial genome is one of the most extensively studied mitochondrial polymorphisms.
Over time, most mitochondrial genes have jumped into the nucleus.
Most mitochondrial genomes are circular, although exceptions have been reported.
Therefore, mitochondrial polymorphisms are strong candidates as markers of risk for many diseases, including breast cancer.
We analyze the correlation between mitochondrial polymorphisms and the longevity phenotype using two different methods.
Most mitochondrial proteins are encoded by nuclear DNA.
These hypotheses predict different patterns of mitochondrial polymorphisms.
Most mitochondrial ROS are detoxified to residual molecules through mitochondrial respiratory chain (MRC) activity.
Most mitochondrial protein precursors are synthesized in the cytosol and subsequently imported into the mitochondrial matrix.
For each individual, we extracted informative mitochondrial polymorphisms (SNPs detected among individuals) from the RAD tags and concatenated them into the final mitochondrial sequence with 92 variable positions.
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