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The herein developed technology comes as solution to the two-dimensionality issue that exists in most microfluidic devices and can relate to a variety of tissue engineering applications.
Quantitative analysis of molecular diffusion is a necessity for the efficient design of most microfluidic devices as well as an important biophysical method in its own right.
In most microfluidic devices, single or multiple dilutions of reagents are required to perform reactions or measurements over a range of concentrations using a set of sample solutions to fill the inlets.
However, most microfluidic devices have been fabricated by using an irreversible bond between a microchannel and a glass slide, and only a few studies have introduced the interface between tissue slide and a microfluidic device; this also proves that few studies applied to human clinical specimens have been reported in microfluidics.
As shown in Table 1, the throughput is achievable by most microfluidic devices, lying around processing of 2 to 3 mL of blood per hours.
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Most microfluidics devices can be described as tiny assembly lines where reactions are carried out as the samples circulate from one specialized compartment to another through thin channels.
Microfluidic mixer is the most important component in microfluidic devices.
The control of flow in microscale is one of the most important problems in microfluidic devices, which in particular, are used as micro heat exchangers.
Most earlier acoustic-based microfluidic devices were constructed by attaching a bulk acoustic transducer onto a silicon microchannel.
Paper-based microfluidics has proven the ability to provide flow without the use of external pumps or high voltage power (necessary in most silicone or PDMS-based microfluidic devices), but rather by spontaneous capillary action amongst paper fibers (also known as wicking).
One of the most popular methods to fabricate biomedical microfluidic devices is by using a soft-lithography technique.
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