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In contrast, most mice in the ANXA2 shRNA group did not develop macro-metastases.
By day 12 most mice in this study had an increased Ig response to C. rodentium (Figure 2).
Most mice in the WT and the mutant groups presented severe clinical signs associated with septicemia, such as depression, swollen eyes, weakness and prostration during the first 24 h post-inoculation (pi).
After intraperitoneal injection, most mice in the 400 mg/kg group were quiet and inactive.
From figure 3A, we can conclude that most mice in our cohort were not sacrificed because of the appearance of MG tumors (indicated as +, censored).
Most mice in the gemcitabine/PEGPH20 combination cohort experienced stable tumour growth (figure S4) and hyaluronidase activity persisted up to study end point (figure S5).
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Using Cas9 protein combined with mRNA of dual-crRNA and tracrRNA has greatly increased the efficiency (Aida et al., 2015), but in most mice resulted in the modification of a single allele.
Germline miR-126 knockout results in a severe angiogenesis defect with most mice dying in utero (Kuhnert et al., 2008; Wang et al., 2008).
Accordingly, changes in histology after hVEGF-A165 expression were seen in the liver, heart and spleen in most mice, but usually not in the lungs or in the kidneys ( Table 1).
TRAIL/SNS-032 treatment completely eradicated established lung tumors in most mice, as determined by in vivo bioluminescence imaging and subsequent histopathological inspection of lung sections.
Aged p110αD933A/WT mice are leaner than WT littermates and this is a common feature of most mice with mutations in the insulin pathway that provide extended lifespan.
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